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Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis

Christine Espinola-Klein1, Hans J Rupprecht, Christoph Bickel

  • 1Medical Department II, Johannes Gutenberg-University Mainz, Germany. espinola@uni-mainz.de

The American Journal of Cardiology
|March 14, 2007
PubMed

Insights

Lower erythrocyte glutathione peroxidase-1 (GPX-1) activity indicates higher cardiovascular risk, especially in patients with widespread atherosclerosis. This finding highlights GPX-1 as a potential biomarker for predicting future cardiovascular events.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Preventive Cardiology

Background:

  • Erythrocyte intracellular glutathione peroxidase-1 (GPX-1) activity shows an inverse relationship with future cardiovascular events.
  • The prognostic value of GPX-1 activity in relation to the extent of atherosclerosis requires further investigation.

Purpose of the Study:

  • To assess the association between GPX-1 activity and the extent of atherosclerosis.
  • To evaluate the long-term prognostic significance of GPX-1 activity in patients with varying atherosclerotic burdens.

Main Methods:

  • Prospective study of 508 patients undergoing coronary angiography.
  • Atherosclerosis assessment in carotid and leg arteries via sonography.
  • Measurement of erythrocyte GPX-1 activity in washed erythrocytes.

Main Results:

  • GPX-1 activity showed a trend towards decrease with increasing atherosclerotic vascular beds (49.3 U/g Hb in no atherosclerosis vs. 46.0 U/g Hb in 3 beds; p=NS).
  • A significant inverse association was found between GPX-1 activity tertiles and cardiovascular events over 6.5 years (adjusted HR 2.3 for lowest vs. highest tertile; p=0.002).
  • Patients with low GPX-1 activity and multivascular atherosclerosis exhibited the highest event rate (36.9%; p <0.0001).

Conclusions:

  • Decreased red blood cell GPX-1 activity is linked to elevated cardiovascular risk.
  • The combination of low GPX-1 activity and extensive atherosclerosis signifies a particularly high risk for cardiovascular events.

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