Related Experiment Video
Updated: Dec 24, 2025
07:15
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
2.8K
Relationship between pericardial fluid B-type natriuretic peptide and ventricular structure and function.
Li-Ping Chen1, Tie-Min Wei, Le-Xin Wang
1Department of Cardiology, Lishui City Central Hospital, Wenzhou Medical College, Lishui, the People's Republic of China.
Archives of Medical Research
|March 14, 2007
Summary
Pericardial B-type natriuretic peptide (BNP) levels were significantly higher than plasma BNP in patients with ventricular septal defects. Pericardial BNP also correlated with ventricular structure and function.
Area of Science:
- Cardiology
- Biochemistry
Background:
- B-type natriuretic peptide (BNP) is a biomarker for heart failure.
- Investigating pericardial BNP offers insights into cardiac function.
Purpose of the Study:
- To measure pericardial and plasma BNP levels.
- To explore the relationship between pericardial BNP and ventricular structure/function.
Main Methods:
- Collected pericardial fluid and plasma from 18 patients with congenital ventricular septal defect.
- Measured BNP concentrations using established assays.
Main Results:
- Pericardial BNP levels (324.8 pg/mL) were significantly higher than plasma BNP levels (20.8 pg/mL).
- Pericardial BNP strongly correlated with plasma BNP (r=0.85).
- Pericardial BNP showed significant correlations with left atrial diameter, left ventricular dimensions, ejection fraction, right ventricular diameter, and pulmonary artery systolic pressure.
Conclusions:
- Pericardial fluid contains higher concentrations of BNP than plasma.
- Pericardial BNP serves as a relevant biomarker, reflecting ventricular structure and function similar to plasma BNP.
