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Updated: Jul 16, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Classification and treatment of severe ankle articular segment deficits: osteochondral allograft reconstruction
Todd A Irwin1, Joseph X Kou, Paul T Fortin
1Department of Orthopaedic Surgery, William Beaumont Hospital, 3535 W Thirteen Mile Road, Suite 744, Royal Oak, MI 48073, USA.
Abstract:
Severe ankle degeneration can be a devastating problem for young adults. Although ankle fusion continues to be the gold standard, inherent long-term problems are related to this treatment option. Further advances in total ankle prosthetic arthroplasty are needed before this treatment option can be considered suitable in a younger population. The use of fresh osteochondral allograft transplantation can provide an alternative treatment option without precluding future salvage procedures. Future studies may further define the role immunosuppression can play in improving fresh osteochondral allograft viability.

