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Autophagy

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Related Experiment Video

Updated: Jul 16, 2026

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

Autophagy: paying Charon's toll.

Tamotsu Yoshimori¹

¹Department of Cell Regulation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita-Osaka 565-0871, Japan.

|March 14, 2007

Summary

Autophagy, a self-eating process, unexpectedly signals dying cells to ensure their removal. This mechanism is vital for proper embryonic development and tissue formation in mice.

Area of Science:

Cell Biology
Developmental Biology
Molecular Biology

Background:

Autophagy, or self-eating, has known protective roles in cells.
Autophagy is also implicated in programmed cell death (PCD).

Purpose of the Study:

To investigate the role of autophagy in programmed cell death during embryonic development.
To understand the signaling mechanisms by which autophagy influences cell clearance.

Main Methods:

Analysis of autophagy's role in programmed cell death during mouse embryonic development.

Main Results:

Autophagy was found to induce a signal in apoptotic cells.
This signal is essential for the efficient clearance of dying cells.

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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

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Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

Related Experiment Videos

Last Updated: Jul 16, 2026

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

The clearance process mediated by autophagy is crucial for mouse embryonic morphogenesis.

Conclusions:

Autophagy plays a critical, previously unrecognized role in signaling for the clearance of apoptotic cells.
This signaling function of autophagy is indispensable for normal embryonic development.