Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Microscopic polyangiitis].

Christian Pagnoux1, Philippe Guilpain, Loïc Guillevin

  • 1Service de médecine interne, Centre de référence national, Plan Maladies rares, vascularites nécrosantes et sclérodermie systémique, Hôpital Cochin, AP-HP, Université Paris 5 - René Descartes, Paris, France.

Presse Medicale (Paris, France : 1983)
|March 14, 2007
PubMed
Summary

Microscopic polyangiitis, an ANCA-associated vasculitis, typically affects small vessels, causing kidney and lung issues. Treatment varies by prognosis, with high remission rates achieved using corticosteroids and immunosuppressants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic Rhinosinusitis and Nasal Polyps in Eosinophilic Granulomatosis With Polyangiitis: A Scoping Review.

International forum of allergy & rhinology·2026
Same author

Sleep disturbances in patients with vasculitis.

Sleep medicine·2026
Same author

Patients' perspectives of eosinophilic granulomatosis with polyangiitis within the context of a clinical trial.

EULAR rheumatology open·2026
Same author

IgG4-related disease presenting as an omental mass.

BMJ case reports·2026
Same author

Correction: Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Frontiers in immunology·2026
Same author

Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.

Frontiers in immunology·2026

Area of Science:

  • Rheumatology
  • Nephrology
  • Pulmonology

Context:

  • Microscopic polyangiitis (MPA) is a small vessel vasculitis.
  • MPA is part of the ANCA-associated vasculitis (AAV) group.
  • Distinguished from polyarteritis nodosa by the 1994 Chapel Hill nomenclature.

Purpose:

  • To review the clinical manifestations, diagnosis, and treatment of microscopic polyangiitis.
  • To highlight the role of anti-myeloperoxidase (MPO) anti-neutrophil cytoplasmic antibodies (ANCAs) in MPA pathogenesis.
  • To discuss current and emerging therapeutic strategies for MPA.

Summary:

  • MPA presents with glomerulonephritis and alveolar hemorrhage, often associated with anti-MPO ANCAs.
  • Treatment depends on prognostic factors: corticosteroids alone for low-risk, combined immunosuppressants (cyclophosphamide) and plasma exchange for high-risk patients.

Related Experiment Videos

  • Maintenance therapy includes azathioprine or methotrexate; biological therapies are under investigation.

    • Impact:

    • Establishes treatment guidelines based on prognostic factors.
    • Provides insights into the role of anti-MPO ANCAs in MPA.
    • Achieves remission rates over 80% with current regimens, with a 5-year relapse rate lower than Wegener's granulomatosis.