LTP induction modifies functional relationship among hippocampal neurons
Related Experiment Video
Updated: Jul 16, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Sung H Yun1, Deok S Lee, Hyunjung Lee
1Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea.
Abstract:
To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered 'functional connectivity,' as defined by the degree of synchronous firing, among simultaneously recorded neurons in the CA3 region. Interestingly, functional connectivity changed bidirectionally so that the total sum of functional connectivity remained constant. These results demonstrate LTP-induced changes in neuronal functional connectivity and suggest the existence of a normalization mechanism for the total sum of functional connectivity.
More Related Videos
09:39Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
05:01Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
Published on: September 20, 2024
Related Concept Videos
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Role of Hippocampus in Memory