Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developments in laboratory diagnostics for isocyanate asthma.

Adam V Wisnewski1

  • 1Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520-8057, USA. adam.wisnewski@Yale.edu

Current Opinion in Allergy and Clinical Immunology
|March 14, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and validation of genes encoding humoral specificity for the chemical allergen toluene diisocyanate.

PloS one·2026
Same author

Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA-1 in Pathologic Responses to Diisocyanate.

Chemical research in toxicology·2024
Same author

Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers: Results of a Longitudinal Cohort.

Journal of occupational and environmental medicine·2023
Same author

Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue: December 2020-August 2021.

Journal of occupational and environmental medicine·2022
Same author

Glutathione reactivity with aliphatic polyisocyanates.

PloS one·2022
Same author

Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses.

PloS one·2022

Laboratory tests can help diagnose isocyanate asthma and identify workplace exposure. Measuring isocyanate-specific IgE and IgG aids in diagnosing asthma in some workers and serves as a biomarker for exposure.

Area of Science:

  • Occupational Health
  • Immunology
  • Toxicology

Background:

  • Isocyanates are widely used in polyurethane production and are a major cause of occupational asthma.
  • Workplace exposure is a key risk factor, but monitoring and diagnosis are challenging.
  • Current diagnostic methods like specific inhalation challenge are demanding and not widely available.

Purpose of the Study:

  • To review recent advances in laboratory diagnostics for isocyanate-induced asthma.
  • To address the urgent need for efficient tests due to increasing isocyanate use.
  • To improve the diagnosis and exposure assessment of isocyanate asthma.

Main Methods:

  • Literature search of PubMed for articles published in 2005-2006.
  • Screening over 150 articles using keywords related to common isocyanates and asthma.

Related Experiment Videos

  • Focus on advances in understanding pathogenesis and immunoassay development.

    • Main Results:

    • New insights into isocyanate asthma pathogenesis improve existing radioallergosorbent and enzyme-linked immunosorbent assays for IgE and IgG.
    • Development of newer immunoassays based on cellular responses and discovery science readouts.
    • Conventional assays show utility in diagnosing a subset of isocyanate asthma cases.

    Conclusions:

    • Laboratory tests measuring isocyanate-specific IgE and IgG are valuable for diagnosing isocyanate asthma in some workers.
    • These tests can serve as biomarkers of exposure for a larger group of occupationally exposed individuals.
    • Further development of immunoassays is ongoing.