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Difficult to control asthma in children.

Louise Fleming1, Nicola Wilson, Andrew Bush

  • 1Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the National Heart and Lung Institute, London, UK.

Current Opinion in Allergy and Clinical Immunology
|March 14, 2007
PubMed
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Managing difficult childhood asthma involves accurate diagnosis and targeted treatment. Noninvasive inflammation markers aid in monitoring control and treatment effects, balancing efficacy with corticosteroid side effects.

Area of Science:

  • Pediatric Pulmonology
  • Asthma Management
  • Inflammation Biomarkers

Background:

  • Difficult childhood asthma requires careful management due to high corticosteroid doses and potential side effects.
  • Ensuring accurate diagnosis and identifying reasons for poor control are crucial for effective treatment.

Purpose of the Study:

  • To review the systematic approach for managing children with difficult asthma.
  • To highlight the importance of balancing therapeutic efficacy with corticosteroid side effects.
  • To emphasize targeted treatment based on characterized reasons for poor control.

Main Methods:

  • Review of recent data correlating invasive and noninvasive airway eosinophil measurements.
  • Evaluation of noninvasive markers for determining asthma phenotype.

Related Experiment Videos

  • Assessment of evidence for repeated measures in monitoring asthma control and treatment effects.

    • Main Results:

    • Noninvasive inflammation markers correlate with invasive measurements and can identify asthma phenotypes.
    • Repeated noninvasive measures show utility in monitoring control and treatment responses.
    • High-dose corticosteroid side effects and poor treatment adherence remain significant challenges.

    Conclusions:

    • Children with difficult asthma are a diverse group.
    • Noninvasive inflammation markers can improve characterization and monitoring.
    • Further prospective trials are needed for new, phenotype-specific treatments.