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[Crohn's disease presenting with recurrent acute polyradiculoneuropathy]
B El Moutawakil1, M A Rafai, I Gam
1Service de Neurologie, CHU Ibn Rochd, Casablanca, Maroc.
Revue Neurologique
|March 14, 2007
Summary
This case study highlights a rare instance of relapsing polyradiculoneuritis, a neurological disorder, associated with Crohn's disease. Early diagnosis and treatment of the underlying inflammatory bowel disease are crucial for managing neurological symptoms.
Area of Science:
- Neurology
- Gastroenterology
- Immunology
Background:
- Neurological manifestations in Crohn's disease are uncommon, typically involving mononeuropathies and white matter abnormalities.
- Polyradiculoneuritis, a rare neurological complication, is exceptionally infrequent in Crohn's disease patients.
Observation:
- A 33-year-old patient presented with ascending limb weakness, a recurrent episode linked to undiagnosed chronic diarrhea.
- Neurological examination revealed tetraparesis with areflexia and hypotonia, alongside cerebrospinal fluid findings indicative of albumino-cytological dissociation.
- Diagnostic workup confirmed active Crohn's disease as the underlying cause of the relapsing polyradiculoneuritis.
Findings:
- The patient experienced a relapsing polyradiculoneuritis concurrently with active Crohn's disease.
- Treatment with salazopyrine-budesonide led to significant improvement in both gastrointestinal and neurological symptoms over three years.
Implications:
- This case underscores the importance of considering inflammatory bowel disease in patients with unexplained neurological deficits.
- The management of neurological symptoms in Crohn's disease is closely linked to controlling the underlying inflammatory condition.
- Further research is needed to elucidate the precise mechanisms and optimize treatment strategies for neurological complications of Crohn's disease.
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