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Related Experiment Video

Updated: Jul 16, 2026

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Imaging microglial activation in Huntington's disease.

Yen F Tai1, Nicola Pavese, Alexander Gerhard

  • 1Division of Neuroscience and Psychological Medicine, Hammersmith Hospital, Imperial College London, UK.

Brain Research Bulletin
|March 14, 2007
PubMed
Summary

Microglial activation, a marker of brain inflammation, is an early process in Huntington's Disease (HD). This occurs even before symptoms appear, suggesting a key role in HD pathogenesis.

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Area of Science:

  • Neuroscience
  • Neuroinflammation
  • Molecular Imaging

Background:

  • Activated microglia are implicated in Huntington's Disease (HD) pathogenesis.
  • PK11195 is a ligand for peripheral benzodiazepine binding sites on activated microglia.
  • Microglial activation is a potential early biomarker in HD.

Purpose of the Study:

  • To investigate in vivo microglial activation in HD patients and gene carriers.
  • To correlate microglial activation with striatal dopamine D2 receptor dysfunction.
  • To establish microglial activation as an early pathological event in HD.

Main Methods:

  • Positron Emission Tomography (PET) imaging using (11)C-(R)-PK11195.
  • Assessment of microglial activation in symptomatic and presymptomatic HD gene carriers.
  • Correlation analysis with (11)C-raclopride PET measurements of striatal dopamine D2 receptor function.

Main Results:

  • Increased microglial activation was observed in both symptomatic and presymptomatic HD gene carriers.
  • Microglial activation in the striatum correlated with dopamine D2 receptor dysfunction severity.
  • Microglial activation precedes symptom onset in HD.

Conclusions:

  • Microglial activation is an early pathological process in Huntington's Disease.
  • A link exists between microglial activation and neuronal dysfunction in HD.
  • Further longitudinal studies are required to fully understand this link.