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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

Genetic polymorphisms for vascular endothelial growth factor in perinatal complications

Ilona Bányász1, Géza Bokodi, Barna Vásárhelyi

  • 11st Department of Pediatrics, Semmelweis University, 1083 Budapest, Bókay J. u. 53-54., Hungary. banyasz@gyer1.sote.hu

European Cytokine Network
|March 14, 2007
PubMed

Insights

Genetic variations in vascular endothelial growth factor (VEGF) are linked to preterm birth and serious infant complications. Specific VEGF polymorphisms increase risks for necrotizing enterocolitis and acute renal failure in low birth weight infants.

Area of Science:

  • Perinatal Medicine
  • Medical Genetics
  • Neonatology

Background:

  • Low birth weight (LBW) infants face higher risks of perinatal complications due to immature vascular systems.
  • Vascular Endothelial Growth Factor (VEGF), crucial for embryonic blood vessel development, is implicated in these complications.

Purpose of the Study:

  • To investigate the association between functional genetic polymorphisms of VEGF and the risk of preterm birth or perinatal morbidity in LBW infants.

Main Methods:

  • Genotyping of VEGF T-460C, C-2578A, and G+405C polymorphisms in 128 LBW infants using real-time PCR or PCR-RFLP.
  • Comparison of VEGF genotypes with 200 healthy, term neonates.

Main Results:

  • The VEGF+405 C allele was more prevalent in LBW infants (OR: 1.29).
  • VEGF -2578A allele carrier status was an independent risk factor for necrotizing enterocolitis (NEC) (aOR: 2.77).
  • VEGF -2578AA genotype carriers showed a reduced risk of acute renal failure (ARF) (aOR: 0.2).

Conclusions:

  • VEGF G+405C polymorphism may be associated with an increased risk of preterm birth.
  • VEGF C-2578A polymorphism appears to play a role in the pathogenesis of perinatal complications like NEC and ARF in LBW infants.

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