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Related Experiment Videos

Diffusion MR imaging in multiple sclerosis: technical aspects and challenges.

E Pagani1, R Bammer, M A Horsfield

  • 1Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

AJNR. American Journal of Neuroradiology
|March 14, 2007
PubMed
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Diffusion tensor MR imaging aids in multiple sclerosis research by detecting microstructural changes. Advancements in hardware and techniques are improving its reliability for studying white matter tracts.

Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Diffusion tensor (DT) MR imaging is crucial for assessing microstructural changes in multiple sclerosis (MS).
  • It detects alterations within and beyond T2-visible lesions, offering insights into disease progression.
  • Challenges in reproducibility and image quality persist despite its utility.

Purpose of the Study:

  • To critically review diffusion tensor MR imaging models, acquisition, and postprocessing techniques for MS studies.
  • To highlight limitations and potential improvements in DT MR imaging for MS research.
  • To provide a comprehensive understanding of DT MR imaging's strengths and weaknesses in MS.

Main Methods:

  • Discussion of echo-planar imaging as a common acquisition scheme.

Related Experiment Videos

  • Analysis of histogram- and region-of-interest-based methods for DT index analysis.
  • Review of advancements like high magnetic field strengths and parallel imaging.

    • Main Results:

    • DT MR imaging visualizes white matter tract pathways by reflecting axonal fiber orientation.
    • The DT model has limitations in voxels with complex fiber populations.
    • High magnetic fields and multicoil arrays significantly enhance DT MR imaging applications.

    Conclusions:

    • DT MR imaging is valuable for MS research, offering detailed microstructural insights.
    • Improvements in hardware and modeling are essential for enhancing reproducibility and accuracy.
    • This review provides a foundation for designing future diffusion imaging studies in MS.