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Updated: Jul 16, 2026
A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
Published on: June 22, 2022
Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation
Alice S Chen-Plotkin1, Keith A Vossel, Martin A Samuels
1Department of Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA. aschen@partners.org
Abstract:
Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.
