Jove
Visualize
Contact Us

Related Experiment Videos

Esophageal motor dysfunction years after radiation therapy.

H Seeman1, J A Gates, M Traube

  • 1Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.

Digestive Diseases and Sciences
|February 1, 1992
PubMed
Summary

Radiation therapy can cause long-term esophageal motor dysfunction, leading to dysphagia years after treatment. This study highlights the need to consider radiation-induced issues in patients with late-onset swallowing difficulties.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of tracheotomy tube occlusion on upper esophageal sphincter and pharyngeal pressures in aspirating and nonaspirating patients.

Dysphagia·2001
Same author

Solution structures of stromelysin complexed to thiadiazole inhibitors.

Protein science : a publication of the Protein Society·1998
Same author

Clostridium difficile colitis: a possible cause of unexplained elevation of serum alkaline phosphatase levels in patients with AIDS.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1998
Same author

Diffuse pagetoid squamous cell carcinoma in situ of the esophagus: a case report.

Cancer·1997
Same author

Differentiation of achalasia from pseudoachalasia by computed tomography.

The American journal of gastroenterology·1997
Same author

Radiologic and manometric study of the gastroesophageal junction in dysphagia aortica.

Journal of clinical gastroenterology·1995
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Gastroenterology
  • Radiation Oncology
  • Clinical Medicine

Background:

  • Esophageal radiation commonly causes acute esophagitis and strictures.
  • Radiologic studies suggest radiation-induced esophageal motor abnormalities, but clinical and manometric data are scarce.
  • Late-onset dysphagia following esophageal radiation is not well-documented.

Observation:

  • Three patients presented with dysphagia decades after radiation therapy.
  • Symptoms included difficulty swallowing, suggesting esophageal dysfunction.
  • Comprehensive evaluations were performed to determine the cause.

Findings:

  • Radiographic, endoscopic, histologic, and manometric studies confirmed radiation-induced esophageal motor dysfunction in all three patients.
  • The dysfunction presented as impaired esophageal motility, distinct from acute complications.

Related Experiment Videos

  • This indicates a delayed effect of radiation on esophageal function.

    • Implications:

    • Radiation-induced esophageal motor dysfunction should be considered in the differential diagnosis of dysphagia, even many years post-treatment.
    • Manometric evaluation is crucial for diagnosing this condition.
    • Further research is needed to understand the pathophysiology and long-term management of radiation-induced esophageal motor dysfunction.