Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hematological malignancies].

Noriko Usui1

  • 1Division of Oncology and Hematology, Dept. of Internal Medicine, Jikei University School of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 14, 2007
PubMed
Summary

Recent therapeutic strategies show significant progress for older adults with hematological malignancies. Novel agents and combination therapies are improving outcomes across various leukemia and lymphoma subtypes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world data of MDS and CMML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11).

International journal of hematology·2023
Same author

Real-world data of AML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11).

International journal of hematology·2023
Same author

Ultrastructural Basis of the Tension Increase in Sea-Urchin Eggs Prior to Cytokinesis: (microfilament/sea-urchin egg/tension).

Development, growth & differentiation·2023
Same author

Specific induction of self-discrimination by follicle cells in Ciona intestinalis oocytes.

Development, growth & differentiation·2023
Same author

Regional Response to Cytochalasin B of the Equatorial Cell Cortex in Sea-Urchin Eggs during the First Mitosis: (surface architecture/cortical microfilaments/cytochalasin B/sea-urchin egg/first mitosis).

Development, growth & differentiation·2023
Same author

MAGNESIUM ION-REQUIRING STEP IN FERTILIZATION OF SEA URCHINS.

Development, growth & differentiation·2023

Area of Science:

  • Hematology
  • Oncology
  • Geriatric Medicine

Background:

  • Older adults with hematological malignancies face unique treatment challenges.
  • Therapeutic advancements in younger populations are increasingly being translated to older patients.
  • Hematological malignancies remain a significant health concern for the aging population.

Purpose of the Study:

  • To review recent therapeutic strategies for hematological malignancies in older adults.
  • To highlight advancements in treating leukemia, lymphoma, and multiple myeloma in the elderly.
  • To assess the efficacy of novel agents and combination therapies in geriatric oncology.

Main Methods:

  • Review of current literature on therapeutic strategies for hematological malignancies in older adults.
  • Analysis of clinical trial data for various leukemia and lymphoma subtypes.
  • Evaluation of targeted therapies, immunoconjugates, and combination regimens.

Main Results:

  • All-trans retinoic acid and anthracyclines are standard for elderly acute promyelocytic leukemia.
  • Gemtuzumab ozogamicin shows promise in acute myeloid leukemia (AML) for the elderly.
  • Imatinib mesylate is effective for Philadelphia-positive leukemias in older adults.
  • Rituximab-based regimens (R-CHOP, R-CVP) are effective for elderly diffuse large B-cell and follicular lymphomas.
  • High-dose chemotherapy with autologous stem cell transplantation is standard for multiple myeloma in older patients.

Conclusions:

  • Significant progress has been made in treating hematological malignancies in older adults.
  • Novel targeted therapies and combination regimens are improving outcomes.
  • Geriatric-specific considerations are crucial for optimizing treatment strategies in elderly cancer patients.

Related Experiment Videos