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Updated: Jul 16, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
Published on: August 13, 2017
Distal tibial osteoarticular allografts
Luke H Balsamo1, Theodore I Malinin, H Thomas Temple
1Bone and Joint Sports Medicine Institute, Naval Medical Center, Portsmouth, VA, USA.
Distal tibial osteoarticular allografts provide acceptable functional outcomes for limb reconstruction after tumor removal. Achieving bone union between the graft and host bone is the most frequent complication encountered.
Area of Science:
- Orthopedic Surgery
- Oncology
- Biomedical Engineering
Background:
- Osteoarticular allografts are utilized for limb reconstruction after tumor excision.
- Distal tibial allografts are less frequently studied compared to other long bone allografts.
- Limited data exists on the functional outcomes of distal tibial allografts in tumor reconstruction.
Purpose of the Study:
- To evaluate the functional outcomes of distal tibial osteoarticular allografts in tumor reconstruction.
- To identify common complications associated with distal tibial allografts in this context.
Main Methods:
- A survey of operating surgeons was conducted following FDA guidelines.
- Outcomes of 29 distal tibial allografts used for tumor reconstruction were assessed.
- Patient outcomes were evaluated using a questionnaire and the Musculoskeletal Tumor Society (MSTS) score.
Main Results:
- Twelve patient questionnaires were returned, reporting nine complications in eight patients.
- Complications included nonunion (3), fracture (2), arthrosis (2), and delayed union (2).
- No infections were reported; the average MSTS score was 67.3% (72.4% for living patients).
Conclusions:
- Distal tibial osteoarticular allografts demonstrate acceptable functional results for tumor reconstruction.
- Challenges in achieving bone union (nonunion or delayed union) are the primary complications.
- Further research may focus on improving union rates in distal tibial allograft reconstructions.
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