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Related Experiment Video

Updated: Jul 16, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Androgen excess and cardiovascular risk.

M Rizzo1, G B Rini, E Carmina

  • 1Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy.

Minerva Endocrinologica
|March 14, 2007
PubMed
Summary

Androgens may not directly increase cardiovascular risk in women. Metabolic factors and insulin resistance in conditions like polycystic ovary syndrome (PCOS) are more likely contributors to cardiovascular disease.

Related Experiment Videos

Last Updated: Jul 16, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Area of Science:

  • Cardiology
  • Endocrinology
  • Reproductive Health

Background:

  • Cardiovascular diseases (CVD) are a leading cause of death globally, with significant gender disparities in morbidity and mortality rates until advanced age.
  • Hormonal differences, particularly androgen levels, are hypothesized to contribute to gender-based CVD risk variations.
  • Women with polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, exhibit elevated cardiovascular risk despite their youth, prompting investigation into androgens' role.

Purpose of the Study:

  • To investigate the controversial role of androgens in increasing cardiovascular risk.
  • To clarify the association between hyperandrogenism and premature cardiovascular diseases in women with PCOS.
  • To determine whether androgens are an independent risk factor for cardiovascular diseases.

Main Methods:

  • Review of long-term studies examining cardiovascular disease prevalence in women with PCOS.
  • Analysis of the relationship between androgen levels and cardiovascular outcomes.
  • Evaluation of the contribution of metabolic components, insulin resistance, and adiponectin secretion to cardiovascular risk in PCOS.

Main Results:

  • Long-term studies did not conclusively demonstrate a clear increased risk for cardiovascular morbidity and mortality in women with PCOS.
  • The role of androgens as an independent risk factor for cardiovascular diseases remains controversial and not clearly recognized.
  • Altered cardiovascular risk factors in PCOS appear primarily linked to metabolic dysregulation, including insulin resistance and reduced adiponectin.

Conclusions:

  • Androgens seem to play a limited role in directly inducing cardiovascular risk.
  • Metabolic components of PCOS, such as insulin resistance and altered adiponectin secretion, are the main drivers of cardiovascular risk in affected women.
  • Further research is needed to fully elucidate the complex interplay of hormonal and metabolic factors in female cardiovascular health.