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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Drug-induced ocular inflammatory diseases.

Frederick W Fraunfelder¹

¹The National Registry of Drug-Induced Ocular Side Effects, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239-4197, USA. eyedrug@ohsu.edu

Drugs of Today (Barcelona, Spain : 1998)

|March 14, 2007

Summary

Drug-induced ocular inflammation, including conjunctivitis and uveitis, can occur through various administration routes. Early recognition and drug withdrawal are key for prevention and treatment, often requiring ophthalmologist consultation.

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Area of Science:

Ophthalmology
Pharmacology
Toxicology

Background:

Ocular inflammation encompasses conditions like conjunctivitis, uveitis, episcleritis, and scleritis.
Uveitis can be classified anatomically (anterior/posterior) or by inflammatory site (iritis, pars planitis, iridocyclitis).
Numerous medications are implicated in causing ocular inflammation.

Purpose of the Study:

To discuss a selection of drugs associated with drug-induced ocular inflammation.
To highlight the importance of recognizing and managing medication-related ocular side effects.

Main Methods:

Review of literature and existing resources on drug-induced ocular inflammation.
Discussion of drug classes known to cause ocular inflammation.
Reference to specialized registries and textbooks for comprehensive information.

Main Results:

Certain drug classes are associated with various forms of ocular inflammation.
Drugs can be administered systemically, topically, or intracamerally, leading to ocular inflammation.
The precise mechanisms of drug-induced ocular inflammation are often not fully understood.

Conclusions:

Physician recognition and potential drug withdrawal are crucial for managing ocular inflammation.
Prompt consultation with an ophthalmologist is recommended due to the vision-threatening potential of these conditions.
Resources like the National Registry of Drug-Induced Ocular Side Effects offer further information.