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Published on: November 25, 2025
Expected and unexpected gallstones in primary care
Anouk M Speets1, Yolanda Van der Graaf, Arno W Hoes
1Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands. aspeets@umcutrecht.nl
Patients with expected gallstones showed distinct symptoms compared to those with unexpected findings. Upper abdominal ultrasound revealed differences in signs and symptoms, aiding diagnosis.
Area of Science:
- Gastroenterology
- Diagnostic Imaging
- Primary Care Medicine
Background:
- Gallstones are common, often presenting with varied symptoms.
- Distinguishing between expected and unexpected gallstone diagnoses is crucial for patient management.
Purpose of the Study:
- To compare signs and symptoms in primary care patients with expected versus unexpected gallstones.
- To evaluate differences in patient presentation referred for upper abdominal ultrasound (US).
Main Methods:
- Prospective cohort study of 430 patients referred for abdominal US.
- General practitioners (GPs) completed questionnaires pre- and post-US.
- Patients were categorized based on clinical suspicion and US findings of cholelithiasis.
Main Results:
- Gallstones detected in 29% of patients with suspected gallstones, versus 11% without.
- Patients with expected gallstones were more likely to have colicky pain and be referred to specialists.
- Unexpected gallstone patients were more often male, had less pain, and fewer specialist referrals.
Conclusions:
- Upper abdominal US confirmed gallstones in 29% of suspected cases and 11% of incidental findings.
- Significant differences exist in symptoms between expected and unexpected gallstone diagnoses.
- Clinical presentation varies notably between patients with and without confirmed gallstones on US.
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