Related Experiment Video
Updated: Jul 16, 2026
08:08
Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
Recent progress in PYY research--an update report for 8th NPY meeting
1Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, 6th Floor Commonwealth Building, Du Cane Road, London W12 ONN, UK.
Peptides
|March 14, 2007
Summary
The gut peptide PYY(3-36) reduces appetite and promotes weight loss, confirmed in rodents and humans. Its anti-obesity potential is being re-evaluated due to a more complex mechanism of action than initially understood.
Area of Science:
- Endocrinology and Metabolism
- Neuroscience
Background:
- Peptide YY (PYY) is a gut hormone known to regulate appetite.
- Varied experimental results have led to debate regarding PYY(3-36)'s efficacy as an anti-obesity treatment.
Framework:
- Recent studies confirm PYY(3-36)'s anorexigenic effect and weight loss in animal models.
- Human studies also demonstrate anorexia, but optimal administration routes and dosages require further definition.
Implementation:
- Elevated PYY levels post-gastric bypass surgery correlate with weight loss, suggesting a mediating role.
- Obese individuals often exhibit normal or low PYY levels, complicating its direct therapeutic application.
Implications:
- The established ARC model of PYY action on NPY and POMC neurons is being revised.
- Emerging evidence points towards a more intricate mechanism involving vagal afferent signaling pathways.
Related Concept Videos
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:03Step-Growth Polymerization: Overview
Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Many natural and synthetic polymers are produced by...