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Updated: Jul 16, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Th1/Th2 cross-regulation and the discovery of IL-10

Hema Bashyam1

  • 1hbashyam@rockefeller.edu

The Journal of Experimental Medicine
|March 14, 2007
PubMed

In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.

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