Evaluation of texture features for analysis of ovarian follicular development

We examined the echotexture in ultrasonographic images of the wall of dominant ovulatory follicles in women during natural menstrual cycles and dominant anovulatory follicles which developed in women using oral contraceptives (OC). Ovarian follicles in women are fluid-filled structures in the ovary that contain oocytes (eggs). Dominant follicles are physiologically selected for preferential development and ovulation. Statistically significant differences between the two classes of follicles were observed for two co-occurrence matrix derived texture features and two edge-frequency based texture features which allowed accurate distinction of healthy and atretic follicles of similar diameters. Trend analysis revealed consistent turning points in time series of texture features between 3 and 4 days prior to ovulation coinciding with the time at which follicles are being biologically "prepared" for ovulation.