Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Automated topology correction for human brain segmentation.

Lin Chen1, Gudrun Wagenknecht

  • 1Central Institute for Electronics, Research Center Juelich, Juelich, Germany.

Medical Image Computing and Computer-Assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
|March 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

(+)-[<sup>18</sup>F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand-results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer's disease and healthy controls.

European journal of nuclear medicine and molecular imaging·2020
Same author

Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia.

Brain : a journal of neurology·2018
Same author

First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[(18)F]Flubatine.

NeuroImage·2015
Same author

Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (-)-[(18)F]Flubatine in humans.

Nuclear medicine and biology·2014
Same author

Viewpoints on Medical Image Processing: From Science to Application.

Current medical imaging reviews·2013
Same author

Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2013
Same journal

LiftReg: Limited Angle 2D/3D Deformable Registration.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same journal

Inverse Consistency by Construction for Multistep Deep Registration.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same journal

Can Crowdsourced Annotations Improve AI-based Congestion Scoring For Bedside Lung Ultrasound?

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same journal

Equivariant Filters for Efficient Tracking in 3D Imaging.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same journal

Lobar Lung Density Embeddings with a Transformer encoder (LobTe) to predict emphysema progression in COPD.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
Same journal

uniGradICON: A Foundation Model for Medical Image Registration.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention·2026
See all related articles

This study introduces an automated method for correcting topology in 3D magnetic resonance images of the human brain. This technique enhances brain structure reconstruction by eliminating the need for manual adjustments.

Area of Science:

  • Neuroimaging
  • Medical Image Analysis
  • Computational Anatomy

Background:

  • Accurate reconstruction of human brain structures from 3D magnetic resonance imaging (MRI) is crucial for neuroscience research.
  • Manual topology correction of brain images is time-consuming and prone to errors.
  • Topological correctness is a prerequisite for advanced neuroimaging analyses like atlas deformation and surface flattening.

Purpose of the Study:

  • To present a novel, fully automatic method for topology correction in 3D MRI brain data.
  • To improve the efficiency and reliability of human brain structure reconstruction.
  • To facilitate subsequent neuroimaging analyses by ensuring topologically correct data.

Main Methods:

  • An axis-aligned volume sweep approach is employed to detect topological defects (handles and tunnels).

Related Experiment Videos

  • A directed graph construction and analysis are used for handle detection.
  • Simultaneous region growing on foreground and background isolates defects, with size-based removal or filling.

    • Main Results:

    • The method successfully performed automatic topology correction on 256 T1-weighted MRI volumes.
    • Elimination of manual correction steps significantly speeds up the reconstruction process.
    • The automated approach ensures consistent and reliable topological correction.

    Conclusions:

    • The developed method offers a fully automatic and efficient solution for topology correction in brain MRI.
    • This automation is vital for large-scale neuroimaging studies and clinical applications.
    • The topologically corrected data supports advanced analyses, advancing our understanding of brain structure.