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Related Experiment Video

Updated: Jul 16, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Weight development in patients treated with risperidone: a 5-year naturalistic study.

M Neovius¹, J Eberhard, E Lindström

¹Department of Medicine, Karolinska Institutet, Karolinska University Hospital (HS), Stockholm, Sweden. martin.neovius@ki.se

Acta Psychiatrica Scandinavica

|March 16, 2007

Summary

Risperidone treatment caused significant weight gain in psychotic patients, with over 40% experiencing excessive gain. Weight gain stabilized over time, but predictors remained unclear, limiting clinical guidance for managing this side effect.

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Area of Science:

Psychiatry
Pharmacology
Endocrinology

Background:

Antipsychotic medications are crucial for managing psychosis.
Weight gain is a common and concerning side effect of antipsychotic treatment.
Understanding long-term weight changes associated with specific antipsychotics like risperidone is essential for patient care.

Purpose of the Study:

To investigate the annual weight development in a cohort of 215 patients with psychosis treated with risperidone over a 5-year period.
To identify potential predictors of excessive weight gain during risperidone therapy.

Main Methods:

A naturalistic longitudinal study design was employed.
Data were collected over 5 years from 215 patients treated with risperidone.
Body Mass Index (BMI) changes were tracked, and associations with baseline weight, gender, symptoms, illness duration, prolactin, and nicotine consumption were analyzed.

Main Results:

The patient sample was more obese at baseline than the general population and showed a greater increase in mean BMI over the study period.
40.2% of patients experienced excessive weight gain (>7%), weakly associated with baseline weight but independent of other measured factors.
Approximately 72% of the total 5-year weight gain was accumulated within the first 2 years of treatment.

Conclusions:

Risperidone treatment is associated with significant weight gain, which tends to plateau over time.
Few significant predictors for adverse weight development were identified, posing challenges for clinical management.
Further research is needed to better predict and mitigate risperidone-induced weight gain.