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Related Experiment Videos

Centrally infused bradykinin increases baroreceptor reflex sensitivity.

V M Gerken1, R A Santos

  • 1Departamento de Fisiologia e Biofisica, Universidade Federal de Minas Gerais, Brazil.

Hypertension (Dallas, Tex. : 1979)
|February 1, 1992
PubMed
Summary

Central bradykinin infusion enhances baroreceptor reflex sensitivity in rats, improving the heart rate response to blood pressure increases. This suggests a role for kinins in cardiovascular regulation.

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Area of Science:

  • Cardiovascular Physiology
  • Neuroendocrinology

Background:

  • Kinins are present in the central nervous system.
  • Central bradykinin administration can influence blood pressure and heart rate.

Purpose of the Study:

  • To investigate the effect of intracerebroventricular bradykinin infusion on baroreceptor reflex sensitivity in conscious rats.

Main Methods:

  • Rats with intracerebroventricular cannulas were infused with bradykinin or saline.
  • Baroreceptor reflex sensitivity was assessed by measuring heart rate changes in response to induced blood pressure alterations using phenylephrine or sodium nitroprusside.
  • Sensitivity was quantified as the slope of the regression line between heart rate and mean arterial pressure.

Main Results:

Related Experiment Videos

  • Intracerebroventricular bradykinin infusion significantly increased baroreceptor reflex sensitivity for blood pressure increments after 1 and 3 hours.
  • No significant changes were observed in reflex tachycardia.
  • Basal mean arterial pressure and heart rate remained unchanged during bradykinin infusion.

    • Conclusions:

    • Central bradykinin administration enhances baroreceptor reflex control of heart rate in rats, specifically for blood pressure increases.
    • These findings highlight the role of central kinins in modulating autonomic cardiovascular regulation.