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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Tumor Progression

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Related Experiment Video

Updated: Jul 16, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

[Prothymosin alpha and tumor: current status and perspective].

Mei Wang¹, Ji-Yong Pan

¹Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, Liaoning, PR China.

AI Zheng = Aizheng = Chinese Journal of Cancer

|March 16, 2007

Summary

Prothymosin alpha (ProTalpha), a protein found in mammals, is increasingly linked to cancer development. This review explores its roles in cell processes and potential as a tumor diagnostic and therapeutic target.

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Published on: August 25, 2021

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Last Updated: Jul 16, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

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Published on: March 20, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Area of Science:

Biochemistry
Molecular Biology
Oncology

Context:

Prothymosin alpha (ProTalpha) is a ubiquitous mammalian protein with largely unknown functions.
Emerging evidence suggests ProTalpha's involvement in cancer initiation and progression.

Purpose:

To comprehensively review the current literature on ProTalpha's biological functions.
To discuss ProTalpha's roles in cell proliferation, carcinogenesis, apoptosis, and immune modulation.
To explore ProTalpha's gene expression regulation, molecular mechanisms, and potential in cancer diagnosis and therapy.

Summary:

ProTalpha, a natively unstructured acidic protein, is widely distributed in mammalian tissues.
Its functions are being elucidated, with recent studies highlighting its role in carcinogenesis.
This review consolidates findings on ProTalpha's involvement in key cellular processes and its potential clinical applications.

Impact:

Provides a consolidated overview of ProTalpha's multifaceted roles in biological systems.
Highlights ProTalpha as a potential biomarker and therapeutic target for various cancers.
Facilitates further research into the molecular mechanisms and clinical significance of ProTalpha.