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Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres
Published on: June 1, 2012
[Cellular compatibility of type collagen I scaffold and human adipose-derived stem cells]
Yun-Song Zhang1, Jian-Hua Gao, Feng Lu
1Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yszhang5201314@163.com
Objective:
To study the cellular compatibility of type I collagen scaffold and human adipose-derived stem cells (ADSC(S)) in order to explore appropriate scaffold materials for adipose tissue engineering.
Methods:
The morphology and function of the ADSC(S) were observed by inverted phase contrast microscope, scanning electron microscope and XTT assay when cocultured type I collagen scaffold with ADSC(S) in vitro. Cells adhesive rates were also calculated.
Result:
ADSC(S) were able to attach, grow and proliferate well on the scaffolds.
Conclusion:
collagen I scaffold exhibits excellent cellular compatibility and can be used as a vehicle for adipose tissue engineering.
