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Human cytomegalovirus glycoprotein B genotype correlates with different symptoms of infected infants

Hong Jin1, Xiuxia Wang, Shuomin Li

  • 1Department of Microbiology and Parasitology, China Medical University, Shenyang, PR China. hong-jin@excite.com

Intervirology
|March 16, 2007
PubMed
Abstract

Insights

Human cytomegalovirus (HCMV) glycoprotein B (gB) genotypes were analyzed in 208 infants. Findings indicate specific gB genotypes correlate with distinct clinical symptoms, suggesting genotype influences infection outcomes.

Area of Science:

  • Virology
  • Pediatric Infectious Diseases

Background:

  • Human cytomegalovirus (HCMV) causes cytomegalic inclusion disease in infants.
  • HCMV strains are classified into four glycoprotein B (gB) genotypes.
  • Limited data exist on the association between HCMV genotypes and clinical symptoms.

Purpose of the Study:

  • To determine HCMV gB genotypes in pediatric patients with varying symptoms.
  • To investigate if gB genotype influences congenital and prenatal HCMV infection outcomes.

Main Methods:

  • HCMV gB genotyping in 208 infected infants' urine specimens.
  • Utilized nested polymerase chain reaction and restriction fragment length polymorphism.

Main Results:

  • The gB1 genotype was dominant among HCMV-infected infants.
  • Significant differences in HCMV gB genotype distribution were observed in infants with jaundice, malformations, and pneumonia.

Conclusions:

  • Relationships exist between HCMV gB genotypes and specific clinical symptoms.
  • The four HCMV gB genotypes may lead to different clinical outcomes in infected infants.

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