Related Experiment Video
Updated: Jul 16, 2026

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Probiotic capsules do not lower plasma lipids in young women and men
K A Greany1, M J L Bonorden, J M Hamilton-Reeves
1Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA.
Objective:
To investigate the effect of probiotic capsules on plasma lipids.
Design:
A randomized, single-blinded, placebo-controlled, parallel-arm trial.
Subjects:
Fifty-five normocholesterolemic subjects ages 18-36 (33 premenopausal women and 22 men).
Intervention:
Each subject consumed either three probiotic capsules each containing a total of 10(9) colony-forming units Lactobacillus acidophilus and Bifidobacterium longum and 10-15 mg fructo-oligosaccharide or three placebo capsules daily for 2 months (men) or two menstrual cycles (women). Plasma lipids were measured before and following the intervention (during the early follicular phase for women).
Results:
Plasma concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride were not altered by consumption of probiotic or placebo capsules and were not different between treatment groups following the intervention.
Conclusions:
These results do not support a beneficial effect of Lactobacillus acidophilus strain DDS-1 and Bifidobacterium longum strain UABL-14 on plasma lipids in normocholesterolemic young women and men.
Sponsorship:
Supported by the Minnesota Agricultural Experiment Station and UAS Laboratories.
Related Concept Videos
Probiotics
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Drugs for Treatment of Constipation-Predominant IBS
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Microbiota Modulation by Antibiotics
Lipid Digestion