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Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins
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The folding and evolution of multidomain proteins

Jung-Hoon Han1, Sarah Batey, Adrian A Nickson

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

Nature Reviews. Molecular Cell Biology
|March 16, 2007
PubMed
Summary

Multidomain proteins, common in eukaryotes, often fold independently when domain interfaces are small or unstructured. Evolutionary mechanisms help minimize interdomain misfolding issues.

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