Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic control of PDX1 and NGN3 by a computationally designed PRC2 inhibitor enforces pancreatic endocrine differentiation from pluripotent stem cells.

Research square·2026
Same author

Human iPSC-derived salivary gland organoids model diabetic salivary gland dysfunction.

bioRxiv : the preprint server for biology·2025
Same author

Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells.

iScience·2024
Same author

Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma.

Cell death & disease·2023
Same author

Bone marrow chimerism breaks the barrier to pancreatic islet transplantation.

Cell reports·2022
Same author

Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response.

Clinical cancer research : an official journal of the American Association for Cancer Research·2021

Related Experiment Video

Updated: Jun 20, 2026

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis
14:28

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Published on: March 16, 2016

Netrins: beyond the brain.

Vincenzo Cirulli1, Mayra Yebra

  • 1University of California San Diego, Department of Pediatrics, National Center for Microscopy and Imaging Research, Whittier Institute for Diabetes, La Jolla, California 92037, USA. vincenzo@ncmir.ucsd.edu

Nature Reviews. Molecular Cell Biology
|March 16, 2007
PubMed
Summary

Netrins, guiding proteins, are crucial for nervous system development and also regulate cell functions in non-neuronal tissues. Their diverse roles are increasingly recognized, including through non-classic receptors.

More Related Videos

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5
10:49

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5

Published on: February 14, 2022

Related Experiment Videos

Last Updated: Jun 20, 2026

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis
14:28

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Published on: March 16, 2016

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5
10:49

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5

Published on: February 14, 2022

Area of Science:

  • Molecular Biology
  • Developmental Neuroscience
  • Cell Biology

Background:

  • Netrins are secreted proteins named from the Sanskrit word 'netr' meaning 'one who guides'.
  • They are well-established as critical guidance cues for neuronal development in the central nervous system.
  • Emerging evidence suggests broader roles in non-neuronal tissues.

Purpose of the Study:

  • To review the expanding roles of netrins beyond the central nervous system.
  • To highlight the involvement of netrins in diverse cellular processes in non-neuronal tissues.
  • To discuss the implications of non-classic netrin receptor interactions.

Main Methods:

  • Literature review of recent studies on netrin function.
  • Analysis of netrin involvement in cell adhesion, motility, proliferation, differentiation, and survival.
  • Examination of signaling pathways involving both classic and non-classic netrin receptors.

Main Results:

  • Netrins regulate fundamental cellular processes including adhesion, motility, proliferation, differentiation, and survival in various non-neuronal tissues.
  • These functions are sometimes mediated through receptors distinct from the classic netrin receptors.
  • This expands the known biological significance of the netrin family.

Conclusions:

  • Netrins are versatile signaling molecules with roles extending far beyond neuronal guidance.
  • The discovery of non-classic netrin receptor interactions broadens the scope of netrin biology.
  • Further research into netrin functions and receptors holds promise for understanding and potentially treating various diseases.