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Updated: Jul 16, 2026
03:43
Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
[Endocannabinoids: the inside plant]
1Instituto de Investigaciones Farmacológicas, CONICET, Buenos Aires, Argentina. eadler@ffyb.uba.ar
Vertex (Buenos Aires, Argentina)
|March 16, 2007
Summary
The brain produces anandamide, an endogenous compound mimicking marihuana effects by activating cannabinoid receptors. This compound is involved in reward pathways and has potential therapeutic applications.
Area of Science:
- Neuroscience
- Biochemistry
- Pharmacology
Context:
- Endogenous cannabinoids, like anandamide, interact with cannabinoid CB1 receptors in the brain.
- These receptors are located in reward circuits, suggesting a role in addiction and mood.
- Anandamide synthesis is linked to physical activity and stress responses.
Purpose:
- To explore the synthesis, function, and therapeutic potential of anandamide.
- To understand the role of endogenous cannabinoids in neurobiology and physiology.
- To investigate the effects of cannabinoid receptor modulation.
Summary:
- An endogenous compound, anandamide, is synthesized in the brain and peripheral tissues, binding to cannabinoid CB1 receptors.
- Anandamide mimics the effects of delta 9 tetrahydrocannabinol (THC), the psychoactive component of marihuana.
- It is involved in neurobiological mechanisms of drug addiction and is produced in response to physical activity.
Impact:
- Blockade of CB1 receptors can induce anorexia, offering a potential target for obesity treatment.
- Activation of CB1 receptors exhibits appetite stimulant, antiemetic, and analgesic properties.
- These properties suggest potential therapeutic uses for anandamide and related compounds in managing appetite, nausea, pain, and addiction.
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