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Overactive bladder in diabetes: a peripheral or central mechanism?
Chiharu Yamaguchi1, Ryuji Sakakibara, Tomoyuki Uchiyama
1Central Laboratory Unit, Department of Molecular Diagnosis, Chiba University, Chiba, Japan.
Neurourology and Urodynamics
|March 16, 2007
Summary
Overactive bladder (OAB) is common in diabetic cystopathy. Central and peripheral mechanisms, including multiple cerebral infarction, contribute to OAB symptoms in diabetic patients.
Area of Science:
- Urology
- Diabetology
- Neurology
Background:
- Diabetic cystopathy is a common complication of diabetes mellitus.
- Overactive bladder (OAB) symptoms, such as urinary urgency and frequency, can significantly impact quality of life.
Purpose of the Study:
- To investigate the prevalence and characteristics of overactive bladder (OAB) in patients with diabetic cystopathy.
- To explore potential underlying mechanisms, including neurological factors, contributing to OAB in this population.
Main Methods:
- Retrospective analysis of 2300 diabetic cystopathy case records.
- Inclusion of data from lower urinary tract symptoms questionnaires, urodynamic studies, and neurological examinations.
- Brain MRI performed in a subset of patients to assess for neurological abnormalities.
Main Results:
- Diabetic cystopathy was identified in 4% of cases (84 patients).
- Overactive bladder (OAB) was present in 55% of patients with diabetic cystopathy.
- Detrusor overactivity (DO) was observed in 42% of patients, and 76.5% of those with DO had multiple cerebral infarction (MCI).
Conclusions:
- Overactive bladder (OAB) is a frequent manifestation of diabetic cystopathy.
- Both central (e.g., multiple cerebral infarction due to diabetic vasculopathy) and peripheral mechanisms contribute to OAB in diabetic patients.
- Detrusor overactivity (DO) is associated with age and multiple cerebral infarction (MCI).
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