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Updated: Jul 16, 2026

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
Primary signet-ring cell carcinoma of the prostate
T Klimis1, A Margaritopoulou, P Vlahos
1Department of Pathology, 3rd Hospital of Social Security Foundation, Athens, Greece.
Abstract:
We report on an uncommon case of primary prostatic signet-ring cell carcinoma (SRCC) in a 78-year-old man. His prostatic specific antigen (PSA) level at presentation was 9.8 ng/ml. Histologically the tumor had a signet-ring morphology. Detailed immunohistochemical studies confirmed the prostatic origin of this neoplasm. All mucin stains were negative. This aggressive tumor is a distinct variant of primary prostatic carcinoma which should be distinguished from artefactual vacuolation of the tumor and metastatic disease.
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