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Plasma fibrinogen concentration in pediatric patients treated with an elimination diet based on soy proteins and

B Mikołuć1, R Motkowski, J Piotrowska-Jastrzebska

  • 1Department of Pediatrics and Developmental Disorders of Children and Adolescents, Medical University of Białystok, ul. Waszyngtona 17, 15-274 Białystok, Poland. bozenam@mp.pl

Advances in Medical Sciences
|March 16, 2007
PubMed

Insights

Children with a family history of circulatory diseases have higher fibrinogen levels, a key atherosclerosis risk factor. Monitoring fibrinogen is crucial for these children, regardless of diet.

Area of Science:

  • Pediatrics
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Atherosclerosis risk factors in children are increasingly studied.
  • Fibrinogen is recognized as a significant marker for atherosclerosis.
  • Family history of circulatory diseases is a critical indicator for early-onset atherosclerosis.

Purpose of the Study:

  • To evaluate fibrinogen levels in children aged 2-6 with and without a family history of circulatory system diseases (FHCAD).
  • To assess the relationship between fibrinogen and traditional atherosclerosis risk markers.
  • To investigate the impact of elimination diets on atherosclerosis markers, particularly fibrinogen.

Main Methods:

  • Study included 134 children (aged 2-6) meeting AAP criteria for FHCAD.
  • Children were categorized based on family history and dietary interventions (elimination diets).
  • Biochemical markers including fibrinogen, total cholesterol, HDL, LDL, triglycerides, and glucose were analyzed.

Main Results:

  • No significant differences in classic biochemical risk factors (cholesterol, triglycerides, glucose) were observed between groups.
  • Children with a positive family history of early circulatory disease (FHCAD+) exhibited statistically higher fibrinogen concentrations.
  • Elimination diet type did not influence fibrinogen levels in the FHCAD+ group.
  • In children without FHCAD, those on casein hydrolysate had lower fibrinogen than those on soy formula.

Conclusions:

  • Pediatricians should inquire about family history of atherosclerosis during initial interviews.
  • Fibrinogen monitoring is recommended for children with a positive family history of circulatory diseases.
  • Early identification of atherosclerosis risk factors in children is essential for preventative strategies.
Abstract

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