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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
Alternative therapies in antibiotic-resistant infection
B Weber-Dabrowska1, M Zimecki, M Kruzel
1Institute of Immunology and Experimental Therapy,e Polish Academy of Sciences, Wrocław, Poland.
Advances in Medical Sciences
|March 16, 2007
Summary
This case report highlights a novel treatment for antibiotic-resistant otitis media. Combining lactoferrin with phage therapy offers a promising solution for stubborn bacterial ear infections.
Area of Science:
- Otolaryngology
- Infectious Diseases
- Microbiology
Background:
- Post-influenza otitis media can be challenging to treat, especially with antibiotic resistance.
- Conventional treatments including steroids and antibiotics showed limited efficacy in this case.
Observation:
- Bacterial strains Staphylococcus hominis and Staphylococcus epidermidis were identified.
- Phage therapy provided only partial symptom relief.
- Oral lactoferrin (LF) administration led to complete bacterial clearance and patient recovery.
Findings:
- Lactoferrin, at 50-mg daily doses, was effective in eradicating Staphylococcus strains.
- Patient recovery correlated with increased myelopoiesis and elevated endogenous serum LF levels.
Implications:
- This combination therapy presents a potential alternative for antibiotic-resistant external ear infections.
- Lactoferrin may play a significant role in managing recalcitrant bacterial infections.
- Further research into phage and lactoferrin synergy is warranted.
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