Related Experiment Video

Updated: Jul 16, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Oxidative stress in burnt children

J Jutkiewicz-Sypniewska1, A Zembroń-Lacny, J Puchała

  • 1The Pediatric Surgical Ward, Public County Hospital, Gorzów Wielkopolski, Poland.

Advances in Medical Sciences
|March 16, 2007
PubMed

Insights

Oxidative stress is present in burnt children, indicated by decreased total antioxidative capacity and increased lipid peroxidation. These markers persist throughout the disease, suggesting a need for antioxidant therapy in pediatric burn patients.

Area of Science:

  • Biomedical Science
  • Pediatric Medicine
  • Burn Injury Research

Background:

  • Burn injuries trigger reactive oxygen species production, leading to oxidative stress and cellular damage.
  • Oxidative stress is a significant factor in the pathophysiology of burn disease.
  • Understanding oxidative stress dynamics in pediatric burn patients is crucial for effective treatment.

Purpose of the Study:

  • To determine the presence and severity of oxidative stress in children with burn injuries.
  • To identify the phase of burn disease when oxidative stress is most pronounced.
  • To assess the duration of oxidative stress following burn injury in pediatric patients.

Main Methods:

  • Study involved 84 pediatric burn patients, divided into lightly burnt (LB) and moderately to severely burnt (SB) groups.
  • Blood samples were collected on days 1, 2, 3, 7, and 21 post-injury.
  • Measured plasma total antioxidative capacity (TAC) and red blood cell lipid peroxidation products (TBARS), comparing to a healthy control group.

Main Results:

  • A significant decrease in TAC was observed in both LB and SB groups compared to controls.
  • TBARS concentration increased on day 1 post-burn and remained elevated throughout the study period.
  • No significant differences in TAC or TBARS were found between the LB and SB groups.

Conclusions:

  • The study confirms the presence of oxidative stress in pediatric burn patients, evidenced by altered TAC and TBARS levels.
  • Oxidative stress is a persistent condition following burn injury in children.
  • Exogenous antioxidant supplementation is recommended for burn-injured children to counteract oxidative stress.
Abstract

More Related Videos

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage

Published on: February 15, 2020

Analysis of Oxidative Stress in Zebrafish Embryos11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Cellular Injury I: Introduction01:00

Cellular Injury I: Introduction

Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...