Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...

Drug Dependence

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

Stimulants

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...

Adrenergic Agonists: Indirect-Acting Agents

Adrenergic Agonists: Indirect-Acting Agents

Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving Access to HIV Prevention Services in Community Pharmacies in the US Southeast: Protocol for a Hybrid Type 1 Effectiveness-Implementation Study.

JMIR research protocols·2025

Same author

Patient-reported outcomes following radiofrequency ablation of the hip: a retrospective study.

Interventional pain medicine·2025

Same author

Patient reported outcomes following genicular nerve radio frequency ablation for osteoarthritis-related knee pain.

Pain management·2025

Same author

Adverse Childhood Experiences increase the lifetime experience of violence poly-victimization among female sex worker in Hai Phong, Vietnam.

Journal of health sciences (Haiphong, Vietnam)·2025

Same author

Baastrup's disease in a patient with multifactorial back pain: a case report.

Pain management·2025

Same author

Sciatic-nerve radiofrequency ablation for phantom limb pain: A case report.

Interventional pain medicine·2024

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Craving and control: methamphetamine users' narratives.

Alexandra M Bruehl¹, Daniel H Lende, Melissa Schwartz

¹Department of Anthropology, Emory University, 1557 Dickey Drive, Atlanta, GA 30322, USA.

Journal of Psychoactive Drugs

|March 16, 2007

Summary

Methamphetamine users experience different types of craving, but these do not always lead to drug use. Many users successfully manage cravings using personal control methods, informing better addiction treatment.

More Related Videos

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Related Experiment Videos

Last Updated: Jul 16, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

Area of Science:

Addiction research
Psychology of substance abuse
Qualitative research methods

Background:

Understanding methamphetamine craving is crucial for addiction treatment.
Existing literature often categorizes craving into distinct types.
The relationship between craving and drug use patterns requires further exploration.

Purpose of the Study:

To explore the lived experience of methamphetamine craving.
To understand how different craving experiences influence methamphetamine use patterns.
To challenge existing typologies of craving and its direct link to use.

Main Methods:

In-depth interviews with 82 active methamphetamine users in Atlanta.
Grounded theory approach utilizing constant comparison for data analysis.
Qualitative analysis of user narratives to identify craving experiences.

Main Results:

Identified three craving types: cue-, drug-, and withdrawal-induced.
Narratives revealed that craving types can overlap and occur simultaneously.
Users reported successful self-management of cravings through personalized control strategies.
Challenged the assumption that all cravings inevitably lead to methamphetamine use.

Conclusions:

Methamphetamine craving is complex and not strictly typological.
Individualized coping mechanisms are effective in managing cravings.
Findings underscore the need to refine drug abuse treatment and harm reduction strategies.
Qualitative insights complement quantitative data on craving.