Related Experiment Video

Updated: Jul 16, 2026

A Rat Model of Compound Acne
03:10

A Rat Model of Compound Acne

Published on: November 1, 2024

Antimicrobial susceptibility of strains of Propionibacterium acnes isolated from inflammatory acne

Walter Gübelin1, M Angélica Martínez, M Teresa Molina

  • 1Department of Dermatology, Faculty of Medicine, University of Chile.

Revista Latinoamericana De Microbiologia
|March 16, 2007
PubMed

Insights

Propionibacterium acnes, a bacteria causing acne, shows low resistance to common antibiotics in Chile. Most strains remain susceptible to penicillin and minocycline, with minimal erythromycin and clindamycin resistance observed.

Area of Science:

  • Dermatology
  • Microbiology
  • Infectious Diseases

Background:

  • Increasing antimicrobial resistance of Propionibacterium acnes to acne treatments is reported globally.
  • Limited data exists on P. acnes antimicrobial susceptibility in Latin America.

Purpose of the Study:

  • To evaluate the antimicrobial susceptibility of P. acnes strains isolated from Chilean patients with inflammatory acne.
  • To provide data on P. acnes resistance patterns in a Latin American population.

Main Methods:

  • Antimicrobial susceptibility testing was performed on 53 P. acnes isolates from skin specimens.
  • Standard microbiological methods were employed to determine resistance profiles.

Main Results:

  • All 53 P. acnes isolates were susceptible to penicillin, minocycline, and nadifloxacin.
  • Low rates of resistance were observed: 3.8% for erythromycin and 1.9% for clindamycin.
  • One isolate showed resistance to lymecycline, with intermediate susceptibility to tetracycline and doxycycline.

Conclusions:

  • Propionibacterium acnes strains in Chile demonstrate high susceptibility to key antibiotics like penicillin and minocycline.
  • The findings suggest current first-line treatments may remain effective for acne in this region.
  • Further surveillance is recommended to monitor potential shifts in antimicrobial resistance patterns.

More Related Videos

Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition07:42

Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition

Published on: September 3, 2016

Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...