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Updated: Jul 16, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Olfactory neuroblastoma (esthesioneuroblastoma): etiopatogenesis, diagnosis, and treatment]
Anna Scińska1, Agnieszka Korkosz, Halina Sienkiewicz-Jarosz
1Klinika Otolaryngologii, Oddział Stomatologii, I Wydział Lekarski AM w Warszawie. scinska@yahoo.com
Introduction:
Esthesioneuroblastoma is a malignant tumour arising from the olfactory epithelium located in the upper part of the nasal cavities. Recent clinical and preclinical studies shed more light on etiopathogenesis, diagnosis, and treatment of this rare malignancy.
Material And Methods:
A systematic review of PubMed/Medline and available Polish literature.
Results:
Molecular studies indicate basal progenitor cells of the olfactory epithelium as the origin of esthesioneuroblastoma. Tumour symptoms are related to its location and typically include: epistaxis, nasal obstruction, olfactory and ophtalmic disturbances as well as craniofacial pain. Esthesioneuroblastoma should be differentiated from embryonic rhabdomyosarcoma, Ewing's sarcoma, melanoma, lymphoma, and pericytoma. A combination of surgery and radiotherapy seems to be the optimum approach to treatment. More aggressive treatment regimens are promising but require further studies.
Conclusions:
Esthesioneuroblastoma is a rare malignant tumour arising from the olfactory epithelium. Early diagnosis and interdisciplinary approach to treatment is vital in the management of the tumour.
