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Updated: Jul 16, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
Published on: February 28, 2021
[Chronic pancreatitis]
Abdou Ali-El-Wafa1, Philippe Maerten, Maria-Anna Ortner
1Division de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne.
Abstract:
New insights in the pathogenesis, classification and the identification of novel risk factors and novel mutations involved in pancreas divisum and in idiopathic pancreatitis have been introduced. Despite novel diagnosis methods, the identification of early pancreatitis, of pancreatitis with minimal morphological changes and the differential diagnosis between chronic pancreatitis and pancreatic carcinoma remain challenges. Treatment of pain associated with pancreatitis remains also difficult; evidence for endoscopic and surgical approaches is still missing. These new discoveries in pathogenesis, etiology and diagnosis methods did not yet lead to improved diagnosis and treatment of chronic pancreatitis.
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Chronic Pancreatitis I: Introduction
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Assessment:
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis I: Introduction

