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Morphing the hyomandibular skeleton in development and evolution.

Charles B Kimmel1, Macie B Walker, Craig T Miller

  • 1Institute of Neuroscience, University of Oregon, Eugene, Oregon, USA. kimmel@uoneuro.uoregon.edu

Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
|March 16, 2007
PubMed
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Evolutionary changes in facial morphology may be explained by alterations in developmental pathways, such as the Endothelin1 (Edn1) pathway. Zebrafish studies reveal Edn1 pathway mutations mimic evolutionary changes in skeletal elements.

Area of Science:

  • Developmental biology
  • Evolutionary biology
  • Genetics

Background:

  • Evolutionary changes in morphology are driven by alterations in developmental regulatory pathways.
  • The Endothelin1 (Edn1) signaling pathway plays a critical role in embryonic development.

Purpose of the Study:

  • To investigate the role of the Edn1 pathway in the evolution of skeletal morphology.
  • To determine if changes in the Edn1 pathway can explain recurrent evolutionary changes in the opercular-branchiostegal skeletal elements.

Main Methods:

  • Developmental genetic analyses in zebrafish.
  • Comparative studies of the opercular-branchiostegal series across actinopterygian lineages.

Main Results:

  • The Edn1 pathway is crucial for hyomandibular patterning in zebrafish.

Related Experiment Videos

  • Phenotypic changes observed in zebrafish mutants for Edn1 signaling components recapitulate evolutionary changes seen in actinopterygian fishes.
  • The Edn1 pathway regulates the number, size, and shape of skeletal elements.

    • Conclusions:

    • The Edn1 pathway is a strong candidate for mediating macroevolution of facial morphology.
    • Developmental genetic studies provide insights into the mechanisms underlying evolutionary morphological changes.