Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

Bioactive lignans from Peperomia duclouxii.

Na Li¹, Jian-Lin Wu, Toshiaki Hasegawa

¹The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. nali9898@hotmail.com

Journal of Natural Products

|March 16, 2007

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mean warming enhances insect resilience to high temperatures: species-specific evidence from two wheat aphids.

Journal of insect physiology·2026

Same author

Metabolomics discover distinct metabolite profiles in children with different airway allergic diseases.

Frontiers in immunology·2026

Same author

Expanded coverage of N-acyl amino acids using one-pot micro synthesis-chemical derivatization-LC-MS strategy: A key to bioactive compounds analysis in fermented soybean.

Food chemistry·2026

Same author

Self-assembling gardenia pectin gel for cholestatic liver injury: Dual mechanisms of hepatoprotection via PPARα activation and gut microbial modulation.

Carbohydrate polymers·2026

Same author

Chemical proteomics reveals sinomenine's anti-inflammatory mechanism through serum protein covalent modification.

Chinese medicine·2026

Same author

A Case of Iatrogenic Benign Cyst Infection Arising at the Anastomosis after Functional End-to-End Anastomosis for Cecal Cancer.

Surgical case reports·2026

Researchers discovered six new lignans from Peperomia duclouxii. One lignan exhibited potent cancer cell growth inhibition, while another demonstrated anti-inflammatory effects by inhibiting intercellular adhesion molecule-1.

Area of Science:

Natural Product Chemistry
Pharmacology
Medicinal Chemistry

Background:

Peperomia species are known sources of bioactive natural products.
Lignans are a diverse class of phenolic compounds with various biological activities.
Investigating the chemical constituents of Peperomia duclouxii may yield novel therapeutic agents.

Purpose of the Study:

To isolate and characterize new lignan compounds from Peperomia duclouxii.
To evaluate the cytotoxic and multidrug resistance (MDR) reversal activities of the isolated compounds.
To assess the anti-inflammatory potential of the isolated compounds.

Main Methods:

Extraction and isolation of compounds from Peperomia duclouxii using chromatographic techniques.
Structure elucidation of new compounds employing Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) data.

More Related Videos

Green Synthesis, Characterization, Encapsulation, and Measurement of the Release Potential of Novel Alkali Lignin Micro-/Submicron Particles

Green Synthesis, Characterization, Encapsulation, and Measurement of the Release Potential of Novel Alkali Lignin Micro-/Submicron Particles

Published on: March 1, 2024

Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!

Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!

Published on: January 26, 2018

Related Experiment Videos

Last Updated: Jul 16, 2026

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

Green Synthesis, Characterization, Encapsulation, and Measurement of the Release Potential of Novel Alkali Lignin Micro-/Submicron Particles

Green Synthesis, Characterization, Encapsulation, and Measurement of the Release Potential of Novel Alkali Lignin Micro-/Submicron Particles

Published on: March 1, 2024

Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!

Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!

Published on: January 26, 2018

Determination of absolute configurations via optical rotation and Circular Dichroism (CD) spectroscopy.

In vitro assays for cytotoxicity, MDR reversal (calcein accumulation), and anti-inflammatory activity (ICAM-1 induction).

Main Results:

Six new lignans (compounds 1-6) and 14 known compounds were identified.
Compound 3 displayed significant cancer cell growth inhibition against VA-13 and HepG2 cell lines (IC50 values 5.3 and 13.2 μg/mL, respectively).
Compound 3 showed superior MDR reversal activity in 2780AD cells compared to verapamil.
Compound 6 exhibited anti-inflammatory activity by inhibiting IL-1α and TNF-α-induced ICAM-1 expression.

Conclusions:

Peperomia duclouxii is a rich source of structurally diverse lignans.
The novel lignans possess promising cytotoxic and MDR reversal properties.
Compound 6 demonstrates potential as an anti-inflammatory agent.