Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synchronization in coupled cells with activator-inhibitor pathways.

S Rajesh1, Sudeshna Sinha, Somdata Sinha

  • 1Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|March 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Asynchronicity yields regularity in coupled neuronal systems.

Chaos (Woodbury, N.Y.)·2026
Same author

Translation, cross-cultural adaptation and validation of short-form patient satisfaction questionnaire (PSQ-18) in Bengali.

International journal of health care quality assurance·2026
Same author

Designing logic gates using active particles.

Physical review. E·2026
Same author

Foot-and-mouth disease adversely affects energy metabolism, surrogate indices of insulin resistance and milk yield till day 180 post-infection in the dairy cow.

Tropical animal health and production·2025
Same author

Strategic synergies: Dispersal and resource allocation in mitigating tipping cascades.

Journal of theoretical biology·2025
Same author

Molecular insights of somatic embryogenesis in coconut.

Molecular biology reports·2025

Robust synchronized cell behavior in tissues can be achieved through random cell connections. Even a few transient random links ensure reliable functional dynamics in cell collectives.

Area of Science:

  • * Systems biology
  • * Biophysics
  • * Theoretical biology

Background:

  • * Cell collectives exhibit complex synchronized behavior.
  • * Understanding factors influencing this synchronization is crucial for biological systems.

Purpose of the Study:

  • * To investigate how local cell dynamics and interaction strength affect spatiotemporal dynamics in cell collectives.
  • * To explore the role of coupling and random connections in achieving synchronized behavior.

Main Methods:

  • * Studying a model of coupled cells with a three-step biochemical pathway (regulated activator-inhibitor reactions).
  • * Analyzing the effects of nearest-neighbor coupling via diffusion of pathway end products.
  • * Investigating the impact of varying interaction strengths and system sizes.

Related Experiment Videos

  • * Introducing random coupling to assess its effect on synchronization.

    • Main Results:

    • * Coupled cells displayed diverse dynamics including chaos suppression, phase synchronization, traveling waves, and intermittency.
    • * Robust complete synchronization was achieved with a small degree of random coupling, surpassing regular coupling's intermittent synchronization.
    • * Random connections significantly enhance the robustness of synchronized functional dynamics.

    Conclusions:

    • * Transient random connections are key to ensuring robust synchronized functional dynamics in cell collectives and tissues.
    • * This finding aligns with recent discoveries of such connections in real cellular systems.
    • * The study provides a theoretical framework for understanding emergent robustness in biological systems.