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Complex phase synchronization in epileptic seizures: evidence for a devil's staircase
J L Perez Velazquez1, L Garcia Dominguez, R Wennberg
1Brain and Behaviour Programme, Department of Paediatrics, University of Toronto and Hospital for Sick Children, Toronto M5G1X8, Canada. jose-luis.perezvelazquez@sickkids.ca
Abstract:
We describe multifrequency phase synchronization in epileptic seizures. Using magnetoencephalographic recordings from three patients suffering generalized seizures, the evidence is presented that, in addition to the commonly studied 1:1 frequency locking, there exists complex multifrequency coordination that, in some cases, follows a classical "devil's staircase." Within the limitations of observing this phenomenon in a clinical experimental setting, these observations reveal that in pathological brain activity, complex frequency locking can be found similar to that identified in certain pathological cardiac re-entrant arrhythmias. This may suggest the existence of similar re-entrant mechanisms active in cerebral neocortex during epileptic seizures.
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