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Hypertrophic cardiomyopathy associated with dexamethasone therapy for bronchopulmonary dysplasia

J C Werner1, R E Sicard, T W Hansen

  • 1Department of Pediatrics, Rhode Island Hospital, Providence 02903.

The Journal of Pediatrics
|February 1, 1992
PubMed

Insights

High-dose dexamethasone therapy in infants with bronchopulmonary dysplasia caused temporary cardiac effects, including myocardial hypertrophy. These changes, assessed by echocardiography, were reversible within six weeks of treatment.

Area of Science:

  • Pediatric Cardiology
  • Neonatology
  • Pharmacology

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in infants.
  • Dexamethasone is used to treat BPD, but its cardiac effects are not fully understood.

Purpose of the Study:

  • To prospectively evaluate potential cardiac effects of high-dose dexamethasone therapy in infants with BPD.

Main Methods:

  • Prospective evaluation of 13 respirator-dependent infants with BPD.
  • Two-dimensional and M-mode echocardiography used for cardiac assessments.
  • Dexamethasone administered at 500 mcg/kg/day, tapered over 6 weeks.

Main Results:

  • Significant increases in interventricular septum and ventricular free wall thickness observed.
  • Systolic anterior motion of the mitral valve noted in 7/13 infants.
  • Cardiac effects were transient, peaking by week 3 and resolving by week 6.

Conclusions:

  • Dexamethasone therapy is associated with transient myocardial hypertrophy in infants with BPD.
  • The exact mechanisms and cardiopulmonary implications of these cardiac changes require further investigation.

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