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Updated: Jul 16, 2026
12:16
Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
Published on: March 13, 2013
Putative cancer stem cells in cutaneous malignancies.
Maria R Kamstrup1, Robert Gniadecki, Gunhild L Skovgaard
1Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark. mk43@bbh.hosp.dk
Experimental Dermatology
|March 16, 2007
Summary
Cancer stem cells drive tumor growth and relapse in various cancers. This overview explores their role in skin cancers, highlighting the need for targeted therapies.
Area of Science:
- Oncology
- Dermatology
- Cancer Biology
Background:
- Cancer stem cells (CSCs) are implicated in tumor growth and recurrence in leukaemia, brain, and breast cancers.
- CSCs are hypothesized to maintain tumor progression and cause treatment resistance.
Purpose of the Study:
- To review current evidence for CSCs in cutaneous malignancies.
- To discuss the significance of CSC characterization for novel therapeutic strategies.
Main Methods:
- Literature review of experimental data on CSCs in skin cancers.
- Analysis of studies investigating CSC markers and functions in cutaneous malignancies.
Main Results:
- Evidence suggests CSCs contribute to the pathogenesis of skin carcinoma, malignant melanoma, and cutaneous T-cell lymphoma.
- Putative CSCs are identified in various skin cancers, though their precise characterization is ongoing.
Conclusions:
- CSCs play a crucial role in the development and relapse of skin cancers.
- Targeting CSCs holds promise for more effective treatments for cutaneous malignancies.
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