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Related Experiment Video

Updated: Jul 16, 2026

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
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The astrocytic response towards invasive meningiomas.

L Zeltner1, J Schittenhelm, M Mittelbronn

  • 1Institute of Brain Research, University of Tübingen, Tübingen, Germany.

Neuropathology and Applied Neurobiology
|March 16, 2007
PubMed
Summary

Subpial astrocytes disappear as brain-invasive meningiomas infiltrate, suggesting their survival depends on an intact pial-glial basement membrane. This study examined astrocyte presence and basement membrane integrity in various meningioma grades.

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Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
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Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
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Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

Area of Science:

  • Neuroscience
  • Oncology
  • Cell Biology

Background:

  • Meningiomas can invade brain tissue, disrupting the pial-glial basement membrane.
  • The behavior of subpial astrocytes at the tumor-brain interface during invasion is not well understood.

Purpose of the Study:

  • To investigate the fate of subpial astrocytes and the integrity of the basement membrane in brain-invasive meningiomas.
  • To correlate astrocyte presence and basement membrane status with meningioma grade (WHO I, II, III).

Main Methods:

  • Immunolabeling of 35 brain-invasive meningioma samples (WHO grades I, II, III).
  • Used anti-collagen IV for basement membrane, and CD44, SPARC, GFAP for astrocytic markers.
  • Analyzed astrocyte presence and basement membrane integrity at the tumor-brain interface and in deep brain parenchyma.

Main Results:

  • Astrocytes were present at the tumor-brain interface in most meningiomas across all WHO grades.
  • Astrocyte presence correlated with an intact basement membrane in lower-grade meningiomas.
  • Meningiomas invading deep brain parenchyma lacked both astrocytes and basement membrane material.

Conclusions:

  • Subpial astrocytes disappear from the tumor-brain interface during meningioma infiltration.
  • The survival of subpial astrocytes may be dependent on an intact pial-glial basement membrane.