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Updated: Jul 16, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Simultaneous off-pump coronary artery bypass surgery and pulmonary resection]
Xue-feng Qiu1, Nian-guo Dong, Tie-cheng Pan
1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. qxf027@163.com
Combined off-pump coronary artery bypass grafting (OPCAB) and pulmonary resection is a safe and effective treatment for patients with both heart and lung disease. This combined approach may reduce postoperative complications in these complex cases.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Oncology
Context:
- Concomitant coronary artery and pulmonary disease presents a complex surgical challenge.
- Off-pump coronary artery bypass grafting (OPCAB) offers an alternative to traditional bypass methods.
- Pulmonary resection is indicated for various lung pathologies, including malignancy and severe COPD.
Purpose:
- To evaluate the safety and efficacy of combined OPCAB and pulmonary resection.
- To assess the outcomes of patients undergoing simultaneous cardiac and lung procedures.
- To determine the impact of OPCAB on postoperative complications in patients requiring pulmonary resection.
Summary:
- Seven patients with coronary artery disease and pulmonary disease underwent combined OPCAB and pulmonary resection.
- OPCAB preceded lung procedures, with sternotomy as the preferred approach.
- No in-hospital mortality occurred; one late death and minor complications were observed. Five patients had malignant tumors, and two had severe COPD. Follow-up showed no myocardial ischemia, with one local recurrence.
Impact:
- Combined OPCAB and pulmonary resection is a safe and effective strategy for managing patients with concurrent heart and lung conditions.
- This approach may lead to a reduced incidence of postoperative complications compared to separate procedures.
- The study highlights the feasibility of managing complex cardiosurgical and thoracic cases in a single operative setting.
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