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Updated: Jul 16, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[Acromegaly: new principles for treatment]
Jens Otto Lunde Jørgensen1, Ulla Friis Feldt-Rasmussen, Marianne Andersen
1Arhus Universitetshospital, Arhus Sygehus, Medicinsk Afdeling M, Arhus C. jolj@dadlnet.dk
Abstract:
Acromegaly is a rare condition usually caused by a GH secreting pituitary tumor. Rigorous control of the disease is important in order to bring the mortality rate on level with that of the background population. Surgery is first choice, and it is sufficient in 50-60% of the patients. Treatment with a somatostatin analogue is second choice and normalises GH hypersecretion in 60% of the patients; tumor shrinkage occurs in 30%. A newly developed GH receptor antagonist, pegvisomant, seems to offer complete suppression of GH activity in most patients and also improves glucose tolerance. The disadvantages of pegvisomant include lack of suppression of tumor activity and a high cost.
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